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L-Citrulline

L-Citrulline is a nitric-oxide precursor with moderate evidence for small resistance-exercise endurance benefits.

How it counts: Counts toward the grade

One of the core ingredients the Dose score (and so the grade) is built on. A product earns credit for it up to the clinical dose.

Clinical dose
4,000โ€“8,000 mg
Safety ceiling
โ€”
Evidence
moderate
Category
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Evidence summary

Research confidence: high

base form; 6 g citrulline malate 2:1 โ‰ˆ 4 g L-citrulline. The meta-analysis's most common protocol (8 g CM, 2:1 mass ratio) yields โ‰ˆ5.3 g L-citrulline and produced a small but significant increase in reps-to-failure (~3 reps, +6.4%); dose-response was flat above ~8 g CM.

Research sources

Dosed at or above clinical in

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