Focus
Dendrobium nobile Stem Extract
Dendrobium nobile extract is a botanical focus ingredient without isolated human pre-workout evidence.
How it counts: Not part of the score
We show it on the label and count it as disclosed, but it never affects Dose, any sub-score or the grade. The basis below explains why.
- Clinical dose
- No established clinical dose
- Safety ceiling
- —
- Evidence
- weak
- Category
- Focus
Evidence summary
Research confidence: low
No pre-workout reference dose. A manufacturer-sponsored trial of a multi-ingredient pre-workout containing a Dendrobium extract reported higher subjective energy and concentration but no objective exercise-performance or body-composition benefit; the formula also raised systolic and diastolic blood pressure and does not isolate this botanical or verify a Dendrobium nobile stem 10:1 extract. Reviews of D. nobile and dendrobine are largely preclinical or concern chronic traditional-medicine uses, not acute use by healthy athletes. A 10:1 extract ratio states raw-herb concentration and does not establish an active-alkaloid yield.
Research sources
- Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of safety (JISSN 2014)(opens in new window)
- Dendrobine: A neuroprotective sesquiterpenic alkaloid for the prevention and treatment of diseases — a review (2024)(opens in new window)
Dendrobine is a major Dendrobium nobile alkaloid, but the reported cognitive and neuroprotective evidence summarized by the review is preclinical and does not establish an acute human pre-workout dose.
- A methamphetamine analog (N,alpha-diethyl-phenylethylamine) identified in a mainstream dietary supplement (Drug Testing and Analysis 2014)(opens in new window)
The stimulant detected in Craze was undeclared N,alpha-DEPEA and had not been identified in any plant, including Dendrobium. This supports treating the Craze episode as product adulteration, not evidence that authentic Dendrobium nobile naturally supplies that stimulant.