Strength
Adenosine 5′-Triphosphate Disodium (Peak ATP)
Peak ATP is oral adenosine triphosphate with moderate evidence for acute repetition performance at 400 mg.
How it counts: Shown for reference, not the grade
We list its clinical dose so you can check a label, but it doesn’t move the grade or a sub-score.
- Clinical dose
- 400 mg
- Safety ceiling
- —
- Evidence
- moderate
- Category
- Strength
Evidence summary
Research confidence: medium
400 mg is the only acute dose with a statistically significant improvement in first-set repetitions in a 100/200/400 mg dose-response trial; 100 and 200 mg did not improve performance. Other small randomized trials at 400 mg report either higher training volume or reduced fatigue without a strength increase. Set effMin=effMax=400 because the evidence does not establish benefit below that dose.
Research sources
- Dose Response of Acute ATP Supplementation on Strength Training Performance (Jäger et al., Front Sports Act Living 2021)(opens in new window)
- A Single Dose of Oral ATP Supplementation Improves Performance and Physiological Response During Lower Body Resistance Exercise (Freitas et al., J Strength Cond Res 2019)(opens in new window)
Randomized double-blind crossover in 11 resistance-trained men: a single 400 mg dose increased total squat training volume versus placebo.
- Acute Effect of Oral Adenosine Triphosphate (ATP) Supplementation on Muscular Performance in Trained Adults (Fambrini et al., J Diet Suppl 2024)(opens in new window)
Randomized double-blind crossover in 18 trained men: 400 mg did not improve strength indicators but reduced the decline in knee-extension performance across repeated sets.