Energy
Methylliberine (Dynamine)
Methylliberine is a stimulant-like purine alkaloid with safety and absorption data but no isolated efficacy trial.
How it counts: Counts toward stim level, not the grade
It isn’t dose-scored. Instead it raises the product’s stim level, so you can see how much kick you’re getting.
- Clinical dose
- 50–100 mg
- Safety ceiling
- 100 mg
- Evidence
- weak
- Category
- Energy
Evidence summary
Research confidence: low
100 mg/day tested safe over 4 weeks; a separate human PK study (medRxiv 2021) used 25-100 mg acute doses. No independent human efficacy RCT isolates methylliberine's ergogenic/cognitive effect -- range reflects doses studied for safety/PK, not a demonstrated effect size.