Focus
Mango leaf extract (Zynamite)
Mango leaf extract is a mangiferin source with early cognition data, but label doses are below studied amounts.
How it counts: Not part of the score
We show it on the label and count it as disclosed, but it never affects Dose, any sub-score or the grade. The basis below explains why.
- Clinical dose
- No established clinical dose
- Safety ceiling
- —
- Evidence
- weak
- Category
- Focus
Evidence summary
Research confidence: low
No reference dose. Mango leaf extract is rich in mangiferin, a plant polyphenol, and is not a stimulant: 300 mg did not change heart rate or blood pressure. That 300 mg dose improved attention and memory accuracy for up to 5 hours in 70 adults (Wightman 2020), and the exercise studies used 140 mg taken together with quercetin or luteolin, which pre-workouts rarely include. Pre-workouts typically carry about 70 mg, half the smallest dose tested in exercise and under a quarter of the cognitive dose; the trials were funded by, supplied by or co-authored with the manufacturer (Nektium).
Research sources
- Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study (Wightman et al., Nutrients 2020)(opens in new window)
- Acute Supplementation of Soluble Mango Leaf Extract (Zynamite S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study (Castellote-Caballero et al., Pharmaceuticals 2025)(opens in new window)
119 students, 100 mg or 150 mg of the soluble form (Zynamite S): better processing speed and cognitive flexibility and less tension and confusion; no memory effect. Sponsored by Nektium; Nektium co-authors.
- Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans (Gelabert-Rebato et al., Front Physiol 2018)(opens in new window)
30 young adults, 140 mg/day mango leaf extract (60% mangiferin) plus luteolin or quercetin for 48 h: sprint peak and mean power up 5-7%. Never tested without the co-flavonoid. Partly financed by Nektium, which supplied the material.
- A Single Dose of The Mango Leaf Extract Zynamite in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women (Gelabert-Rebato et al., Nutrients 2019)(opens in new window)
40 adults, double-blind crossover: 140 mg Zynamite + 140 mg quercetin 1 h before exercise raised Wingate peak power 2.8-3.8%. Combination product, not mango leaf extract alone.